At One and Two Discovery Square, world-changing ideas in modern medicine are becoming reality. These purpose-built life sciences buildings are designed to accelerate innovation.
Just steps from Mayo Clinic’s world-renowned research, clinical, and education campuses, tenants benefit from unmatched access to top medical professionals and pioneering science. This direct connection shortens the distance from discovery to patient care.
Innovation thrives here because connection is intentional. Shared spaces and curated experiences spark the kind of “structured serendipity” that leads to new ideas, fresh partnerships and meaningful breakthroughs.
One Discovery Square is the original anchor of Rochester’s innovation district—a purpose-built, 81,000-square-foot life science hub where discovery is woven into the design. Nearly fully leased, the building is home to startups, researchers, and educators working in close proximity to Mayo Clinic collaborators. With curated tenant programming, shared lab access, and a vibrant, high-touch environment, One Discovery Square fosters early-stage innovation and a culture of connection that accelerates scientific progress.
Now leasing, Two Discovery Square offers 120,000 square feet of flexible lab and office space designed for growth-stage companies and enterprise tenants. Positioned next door to Mayo Clinic, the building expands on the Discovery Square vision with scalable infrastructure, modern amenities, and room to grow. Whether you’re moving from concept to commercialization or expanding an existing footprint, Two Discovery Square delivers the space, support, and ecosystem to make your next breakthrough possible.