One Discovery Square

With Mayo Clinic at its core, One Discovery Square is THE ONLY collaborative space where higher education, startups and Mayo Clinic's partner companies can work together. Here, shared passion and purpose unite to bring forth what’s next in the life sciences.

Mortenson welcomed the first tenants to One Discovery Square in June 2019 and has since proven that its unique combination of intentional design and creative, ongoing professional programming results in structured serendipity between tenants and among tenants and the broader medical community in Rochester.

One Discovery Square features collaborative team spaces, casual seating areas, multiple shared conference rooms and a spacious courtyard where your team can ideate, reflect and relax. Grab a cup of coffee at Café Steam in the morning on your way to work or for a quick pick-me-up.

As with Two Discovery Square, One Discovery Square has infrastructure for wet and dry labs and GMP facilities as well as high-speed broadband for reliable digital connectivity. 

Tenant Profiles


University of Minnesota Rochester

The University of Minnesota Rochester (UMR) inspires transformation in higher education through innovations that empower graduates to solve the grand health challenges of the 21st century. UMR students utilize lab and classroom space at One and Two Discovery Square, providing them an opportunity to intersect and synergize with other tenants.

Tenant Profiles


Rion is a clinical-stage regenerative medicine company focused on developing a new type of room temperature stable biologic – exosome therapeutics – that activate the body’s innate ability to heal. Rion’s mission is to develop innovative exosome therapeutics that are clinically impactful and broadly accessible.

Tenant Profiles

Center for Regenerative Medicine

Mayo Clinic established the Center for Regenerative Medicine in 2011 to research and develop technologies to repair diseased, injured or congenitally defective tissues and organs – a vital component of medical and surgical practice in the coming years. Efforts in each of the center’s programs, which build on Mayo’s extensive research resources and clinical practice, span the full spectrum of discovery science, translational research and clinical application. 

Tenant Profiles

Advanced Diagnostics Laboratory

The Advanced Diagnostics Laboratory, a collaboration between Mayo Clinic’s Department of Laboratory Medicine and Pathology and the Center for Individualized Medicine, increases the pace of innovation by supporting pioneering projects in disruptive technologies, such as multi-omics, artificial intelligence, and digital pathology. It collaborates with tenants in One and Two Discovery Square and elsewhere to increase the lab testing capabilities at Mayo Clinic, accelerate test development in individualized medicine, rapidly implement advanced platforms and technologies, and provide alternate revenue sources.

Tenant Profiles



Aiforia equips pathologists and scientists in clinical, pre-clinical, and academic labs with powerful deep-learning AI and cloud-based technology. Aiforia’s solutions strive to increase the speed, accuracy, and consistency of analyzing large and complex medical images, especially in pathology.

Tenant Profiles

Exact Sciences

Exact Sciences is changing the way we think about detecting and treating cancer. As a leader in cancer testing, it is committed to providing earlier answers and life-changing treatment guidance.

Tenant Profiles


Philips looks beyond technology to the experiences of consumers, patients, providers and caregivers across the health continuum – from healthy living and prevention to diagnosis, treatment and home care. It unlocks insights leading to innovative solutions that enable better care at lower cost. With leading research, design and innovation capabilities, Philips partners with its customers to transform the delivery of healthcare.

Tenant Profiles


Epic develops software to help people get well, help people stay well and help future generations be healthier. Today, more than 250 million patients have a current electronic record in Epic.

Tenant Profiles

Cafe Steam_400

Café Steam

Café Steam is a locally owned, independent coffee shop serving up the best coffees and teas in Rochester. Conveniently located in the atrium of One Discovery Square, Café Steam is committed to supporting businesses in Rochester and throughout Southeastern Minnesota.

Tenant Profiles

Motion Medical by Boston Scientific

Motion Medical by Boston Scientific formalizes a history of collaboration between medical device manufacturer Boston Scientific and Mayo Clinic. The venture aims to accelerate the development of new minimally invasive treatments for many health conditions that impede quality and longevity of life, including medical technologies for interventional cardiology, heart rhythm management, endoscopy, neuromodulation and urology.


What’s here is what’s next.