Researchers benefit from a collaborative environment where complex experiments are supported by Mayo Clinic’s experts, fast-tracking discoveries. The tools and resources available help transform theoretical research into practical, life-changing cures – the kind of advancements that distinguish Mayo Clinic’s reputation for excellence.
Access cutting-edge instruments and technologies
Tap into expert services for basic and clinical research
Accelerate discoveries with high-quality technical support
Benefit from cost-effective resource sharing
Collaborate with world-class Mayo Clinic investigators
Utilize specialized equipment and data analysis services
Enhance your publications and grant acquisitions
Stay ahead with continuously updated research capabilities
One and Two Discovery Square offers more than world-class lab and office space, it’s a launchpad for growth, connection, and clinical impact. Tenants benefit from integrated resources, direct access to Mayo Clinic expertise, and a collaborative environment designed to move ideas forward.
Tenants gain unique opportunities to engage with Mayo Clinic Ventures for regular IP reviews and early insight into emerging technologies. This proximity fosters faster feedback, clearer pathways to commercialization, and strategic alignment with clinical priorities.
Tenants can collaborate with Mayo Clinic clinicians and scientists to evaluate, refine, and co-develop technologies. These expert partnerships help shape innovations for real-world healthcare impact.
With the University of Minnesota Rochester and Mayo Clinic College of Medicine and Science next door, tenants can access a highly skilled talent pool and benefit from customized workforce training programs that evolve with your business needs.
Tenants may access select core laboratory services also available to Mayo Clinic researchers. This includes cutting-edge equipment, capabilities, and support that may be cost-prohibitive to build alone.
On-site property management plans regularly scheduled events to bring tenants together.
One and Two Discovery Square blends work and leisure,
creating a vibrant community where collaboration thrives. Our
strategically designed spaces host diverse events, fostering
connections between tenants, businesses, researchers, and
the Rochester community.
One Discovery Square is the original anchor of Rochester’s innovation district—a purpose-built, 81,000-square-foot life science hub where discovery is woven into the design. Nearly fully leased, the building is home to startups, researchers, and educators working in close proximity to Mayo Clinic collaborators. With curated tenant programming, shared lab access, and a vibrant, high-touch environment, One Discovery Square fosters early-stage innovation and a culture of connection that accelerates scientific progress.
Now leasing, Two Discovery Square offers 120,000 square feet of flexible lab and office space designed for growth-stage companies and enterprise tenants. Positioned next door to Mayo Clinic, the building expands on the Discovery Square vision with scalable infrastructure, modern amenities, and room to grow. Whether you’re moving from concept to commercialization or expanding an existing footprint, Two Discovery Square delivers the space, support, and ecosystem to make your next breakthrough possible.