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Now Leasing!
Two Discovery Square

Colliers International, on behalf of Mortenson, is now leasing Two Discovery Square, a 125,000-square-foot, adaptive, highly secure building with leading-edge technology. As the first WiredScore-Certified building in Rochester, Two Discovery Square will enable digital diagnostics and analyses, imaging, artificial intelligence (AI), and research and development well into the future. 

As more tenants are added to the recently completed Two Discovery Square, the entrepreneurial and collaborative spirit in the Discovery Square District is amplifying greater and greater.

Unprecedented access to Mayo Clinic experts, facilities and services

Tenants of One and Two Discovery Square have unprecedented access to Mayo Clinic experts, labs and research facilities to help speed advances from bench to bedside. Every tenant can meet with Mayo Clinic Ventures for routine reviews of new intellectual property. The collaboration can extend to opportunities for evaluation and co-development of new and existing technologies with input from distinguished clinicians and scientists. 

​Tenants also have a strategic workforce advantage. Mayo Clinic College of Medicine and Science offers cutting-edge programs in biomedical research, medical and clinical education, and entrepreneurship. World-class faculty can tailor innovative training and curriculum to meet companies’ evolving staffing needs. 

Reinforcing Rochester and the Discovery Square District as a hub of medical advancement, Mayo Clinic is constructing the Anna-Maria and Stephen Kellen Building, a new $120-million research facility adjacent to One Discovery Square.

Join the Discovery Square Team

Discovery Square is committed to attracting and retaining the very best talent. Opportunities to join in this unique campus are listed below.

Real Estate Manager

Responds to tenant needs, ensuring that administrative and building technical staff resolve problems promptly. Ensures that services are provided in compliance with policies, procedures, regulations, and contractual obligations and standards. Ensures periodic regular property inspection. Recommends and/or approves alterations, maintenance, and reconditioning as necessary. Bids, secures, and administers service agreements with vendors and suppliers, while achieving the best value for facility products and services. See full job description here.


Sr. Meeting and Event Coordinator

Acts as the primary contact for event clients and responsible for ensuring that the logistics of events are run efficiently, Meeting Host’s standards. Prepares event spaces in advance, assist with vendor space access and ensure vendor safety and insurance requirements are met, support food and beverage service, provide attendee service such as greeting and providing wayfinding, and support event wrap up activities such as billing and clean-up. May support meeting planning activities such as scheduling, providing room set configuration options, audio visual or décor options, or list of recommended food and beverage vendors. See full job description here.




Tenants at One and Two Discovery Square have access to many of Mayo Clinic's Core Services, including:

Genome Analysis Core

  • Genome, Exome and Transcriptome Sequencing
  • Genotyping
  • Gene Expression

Biospecimen Accessioning Processing Core

  • Nucleic Acid Extraction
  • Plasma/Serum Separation

​Immunochemical Core

  • Mass Spec, Cobas, Elisa and RIA Platforms for Small Molecule Analysis and Other Analytes 

Metabolomics Core

  • Mass Spectrometers, Liquid and Gas Chromatography Platforms to Identify and Analyze Metabolites 

Microscopy and Cell Analysis Core

  • Electron Microscopy
  • Light Microscopy
  • Flow Cytometry 

​Pathology Research Core

  • Sectioning Both Paraffin-Embedded and Frozen Tissues 
  • Automated Staining for Immunohistochemistry, Immunofluorescence and RNA in Situ hybridization
  • Tissue Microarray Construction with 60 to 360 Cores
  • Digital Analysis of Whole Tissue and TMA Slides
Other core laboratory resources could be available. Please contact Chris Kolbert for more information.

Tenant Profiles


Rion is a clinical-stage regenerative medicine company focused on developing a new type of room temperature stable biologic – exosome therapeutics – that activate the body’s innate ability to heal. Rion’s mission is to develop innovative exosome therapeutics that are clinically impactful and broadly accessible.

Tenant Profiles

Center for Regenerative Medicine

Mayo Clinic established the Center for Regenerative Medicine in 2011 to research and develop technologies to repair diseased, injured or congenitally defective tissues and organs – a vital component of medical and surgical practice in the coming years. Efforts in each of the center’s programs, which build on Mayo’s extensive research resources and clinical practice, span the full spectrum of discovery science, translational research and clinical application. 

Tenant Profiles

Advanced Diagnostics Laboratory

The Advanced Diagnostics Laboratory, a collaboration between Mayo Clinic’s Department of Laboratory Medicine and Pathology and the Center for Individualized Medicine, increases the pace of innovation by supporting pioneering projects in disruptive technologies, such as multi-omics, artificial intelligence, and digital pathology. It collaborates with tenants in One and Two Discovery Square and elsewhere to increase the lab testing capabilities at Mayo Clinic, accelerate test development in individualized medicine, rapidly implement advanced platforms and technologies, and provide alternate revenue sources.

Tenant Profiles

novavita thera

Novavita thera, a Cytotheryx company, is a biomedical research company focused on the development of a consistent, high-quality source of human hepatocytes (HHCs) and the application of those HHCs for multiple research and clinical applications.

Tenant Profiles

Exact Sciences

Exact Sciences is changing the way we think about detecting and treating cancer. As a leader in cancer testing, it is committed to providing earlier answers and life-changing treatment guidance.

Tenant Profiles


Philips looks beyond technology to the experiences of consumers, patients, providers and caregivers across the health continuum – from healthy living and prevention to diagnosis, treatment and home care. It unlocks insights leading to innovative solutions that enable better care at lower cost. With leading research, design and innovation capabilities, Philips partners with its customers to transform the delivery of healthcare.

Tenant Profiles

Thermo Fisher

Thermo Fisher Scientific enables its customers to make the world healthier, cleaner and safer. Whether they are accelerating life sciences research, solving complex analytical challenges, improving patient diagnostics and therapies or increasing productivity in their laboratories, Thermo Fisher supports them. It delivers an unrivaled combination of innovative technologies, purchasing convenience and pharmaceutical services through its industry-leading brands, including Thermo Scientific, Applied Biosystems, Invitrogen, Fisher Scientific, Unity Lab Services and Patheon.

Tenant Profiles


Epic develops software to help people get well, help people stay well and help future generations be healthier. Today, more than 250 million patients have a current electronic record in Epic.

Tenant Profiles

Café Steam

Café Steam is a locally owned, independent coffee shop serving up the best coffees and teas in Rochester. Conveniently located in the atrium of One Discovery Square, Café Steam is committed to supporting businesses in Rochester and throughout Southeastern Minnesota.

Tenant Profiles

Motion Medical by Boston Scientific

Motion Medical by Boston Scientific formalizes a history of collaboration between medical device manufacturer Boston Scientific and Mayo Clinic. The venture aims to accelerate the development of new minimally invasive treatments for many health conditions that impede quality and longevity of life, including medical technologies for interventional cardiology, heart rhythm management, endoscopy, neuromodulation and urology.

What is a WiredScore-Certified Building?

WiredScore Certification assures tenants that Two Discovery Square will facilitate global digital connectivity, providing the speed, coverage and capacity data-driven organizations require. WiredScore-Certified buildings have met rigorous standards and evaluations for resilience and future readiness of the building’s digital infrastructure, mobile coverage, user experience and provider options. 

One Discovery Square

Since opening One Discovery Square in 2019, Mortenson has demonstrated that intentional design, combined with quality professional programming, sparks energy, collaboration and possibility among tenants as well as with others in Rochester’s medical community.

One Discovery Square is a state-of-the-art, life sciences building that fosters knowledge, innovation and collaboration. Current tenants in the 81,000-square-foot building include:

What’s here is what’s next.