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Now Leasing!
Two Discovery Square

Mortenson is now leasing Two Discovery Square, a 125,000-square-foot, adaptive, highly secure building with leading-edge technology. As the first WiredScore-Certified building in Rochester, Two Discovery Square will enable digital diagnostics and analyses, imaging, artificial intelligence (AI), and research and development well into the future. 

As more tenants are added to the recently completed Two Discovery Square, the entrepreneurial and collaborative spirit in the Discovery Square District is amplifying greater and greater.

Unprecedented access to Mayo Clinic experts, facilities and services

Tenants of One and Two Discovery Square have unprecedented access to Mayo Clinic experts, labs and research facilities to help speed advances from bench to bedside. Every tenant can meet with Mayo Clinic Ventures for routine reviews of new intellectual property. The collaboration can extend to opportunities for evaluation and co-development of new and existing technologies with input from distinguished clinicians and scientists. 

​Tenants also have a strategic workforce advantage. Mayo Clinic College of Medicine and Science offers cutting-edge programs in biomedical research, medical and clinical education, and entrepreneurship. World-class faculty can tailor innovative training and curriculum to meet companies’ evolving staffing needs. 

Reinforcing Rochester and the Discovery Square District as a hub of medical advancement, Mayo Clinic is constructing the Anna-Maria and Stephen Kellen Building, a new $120-million research facility adjacent to One Discovery Square.

Join the Discovery Square Team

Discovery Square is committed to attracting and retaining the very best talent. Opportunities to join in this unique campus are listed below.

No current job openings.


Tenants at One and Two Discovery Square have access to many of Mayo Clinic's Core Services, including:

Genome Analysis Core

  • Genome, Exome and Transcriptome Sequencing
  • Genotyping
  • Gene Expression

Biospecimen Accessioning Processing Core

  • Nucleic Acid Extraction
  • Plasma/Serum Separation

​Immunochemical Core

  • Mass Spec, Cobas, Elisa and RIA Platforms for Small Molecule Analysis and Other Analytes 

Metabolomics Core

  • Mass Spectrometers, Liquid and Gas Chromatography Platforms to Identify and Analyze Metabolites 

Microscopy and Cell Analysis Core

  • Electron Microscopy
  • Light Microscopy
  • Flow Cytometry 

​Pathology Research Core

  • Sectioning Both Paraffin-Embedded and Frozen Tissues 
  • Automated Staining for Immunohistochemistry, Immunofluorescence and RNA in Situ hybridization
  • Tissue Microarray Construction with 60 to 360 Cores
  • Digital Analysis of Whole Tissue and TMA Slides
Other core laboratory resources could be available. Please contact Chris Kolbert for more information.

Tenant Profiles


University of Minnesota Rochester

The University of Minnesota Rochester (UMR) inspires transformation in higher education through innovations that empower graduates to solve the grand health challenges of the 21st century. UMR students utilize lab and classroom space at One and Two Discovery Square, providing them an opportunity to intersect and synergize with other tenants.

Tenant Profiles


Rion is a clinical-stage regenerative medicine company focused on developing a new type of room temperature stable biologic – exosome therapeutics – that activate the body’s innate ability to heal. Rion’s mission is to develop innovative exosome therapeutics that are clinically impactful and broadly accessible.

Tenant Profiles

Center for Regenerative Medicine

Mayo Clinic established the Center for Regenerative Medicine in 2011 to research and develop technologies to repair diseased, injured or congenitally defective tissues and organs – a vital component of medical and surgical practice in the coming years. Efforts in each of the center’s programs, which build on Mayo’s extensive research resources and clinical practice, span the full spectrum of discovery science, translational research and clinical application. 

Tenant Profiles

Advanced Diagnostics Laboratory

The Advanced Diagnostics Laboratory, a collaboration between Mayo Clinic’s Department of Laboratory Medicine and Pathology and the Center for Individualized Medicine, increases the pace of innovation by supporting pioneering projects in disruptive technologies, such as multi-omics, artificial intelligence, and digital pathology. It collaborates with tenants in One and Two Discovery Square and elsewhere to increase the lab testing capabilities at Mayo Clinic, accelerate test development in individualized medicine, rapidly implement advanced platforms and technologies, and provide alternate revenue sources.

Tenant Profiles



Aiforia equips pathologists and scientists in clinical, pre-clinical, and academic labs with powerful deep-learning AI and cloud-based technology. Aiforia’s solutions strive to increase the speed, accuracy, and consistency of analyzing large and complex medical images, especially in pathology.

Tenant Profiles

Exact Sciences

Exact Sciences is changing the way we think about detecting and treating cancer. As a leader in cancer testing, it is committed to providing earlier answers and life-changing treatment guidance.

Tenant Profiles


Philips looks beyond technology to the experiences of consumers, patients, providers and caregivers across the health continuum – from healthy living and prevention to diagnosis, treatment and home care. It unlocks insights leading to innovative solutions that enable better care at lower cost. With leading research, design and innovation capabilities, Philips partners with its customers to transform the delivery of healthcare.

Tenant Profiles


Epic develops software to help people get well, help people stay well and help future generations be healthier. Today, more than 250 million patients have a current electronic record in Epic.

Tenant Profiles

Cafe Steam_400

Café Steam

Café Steam is a locally owned, independent coffee shop serving up the best coffees and teas in Rochester. Conveniently located in the atrium of One Discovery Square, Café Steam is committed to supporting businesses in Rochester and throughout Southeastern Minnesota.

Tenant Profiles

Motion Medical by Boston Scientific

Motion Medical by Boston Scientific formalizes a history of collaboration between medical device manufacturer Boston Scientific and Mayo Clinic. The venture aims to accelerate the development of new minimally invasive treatments for many health conditions that impede quality and longevity of life, including medical technologies for interventional cardiology, heart rhythm management, endoscopy, neuromodulation and urology.

What is a WiredScore-Certified Building?

WiredScore Certification assures tenants that Two Discovery Square will facilitate global digital connectivity, providing the speed, coverage and capacity data-driven organizations require. WiredScore-Certified buildings have met rigorous standards and evaluations for resilience and future readiness of the building’s digital infrastructure, mobile coverage, user experience and provider options. 

Discovery Square Campus

Since opening Discovery Square Campus in 2019, Mortenson has demonstrated that intentional design, combined with quality professional programming, sparks energy, collaboration and possibility among tenants as well as with others in Rochester’s medical community.

Discovery Square Campus is a state-of-the-art, life sciences building that fosters knowledge, innovation and collaboration. Current tenants in the 81,000-square-foot building include:

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