One Discovery Square is the original anchor of Rochester’s innovation district—a purpose-built, 81,000-square-foot life science hub where discovery is woven into the design. Nearly fully leased, the building is home to startups, researchers, and educators working in close proximity to Mayo Clinic collaborators. With curated tenant programming, shared lab access, and a vibrant, high-touch environment, One Discovery Square fosters early-stage innovation and a culture of connection that accelerates scientific progress.
Now leasing, Two Discovery Square offers 120,000 square feet of flexible lab and office space designed for growth-stage companies and enterprise tenants. Positioned next door to Mayo Clinic, the building expands on the Discovery Square vision with scalable infrastructure, modern amenities, and room to grow. Whether you’re moving from concept to commercialization or expanding an existing footprint, Two Discovery Square delivers the space, support, and ecosystem to make your next breakthrough possible.